Can protein unfolding simulate protein folding?

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Can protein unfolding simulate protein folding?

Since the discovery that the native structure of a globular protein can fold spontaneously (Anfinsen et al., 1961), numerous experimental and theoretical efforts have been made to elucidate folding pathways, intermediates, transition states, etc. (for recent reviews, see Bryngelson et al., 1995; Fersht, 1995, 1997; Karplus and Šali, 1995; Ptitsyn, 1995; Miranker and Dobson, 1996; Shakhnovich, 1...

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ژورنال

عنوان ژورنال: Protein Engineering Design and Selection

سال: 1997

ISSN: 1741-0126,1741-0134

DOI: 10.1093/protein/10.8.843